cyclic nucleotide phosphodiesterases, type 5

Preferred Label : cyclic nucleotide phosphodiesterases, type 5;

MeSH definition : A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.;

MeSH synonym : phosphodiesterase-5; phosphodiesterase 5; phosphodiesterase v; cgmp-binding, cgmp-specific 3',5'-cyclic nucleotide phosphodiesterase; pde5 phosphodiesterases; phosphodiesterases, pde5; Phosphodiesterase 5A, cGMP-Specific; Phosphodiesterase 5A, cGMP Specific; cGMP-Specific Phosphodiesterase 5A; Phosphodiesterase 5A; Phosphodiesterase Type 5; Type 5, Phosphodiesterase; Phosphodiesterase Type V; Type V, Phosphodiesterase;

MeSH Related Number : EC 3.1.4.17;

Registry Number MeSH : EC 3.1.4.35;

Wikipedia link : https://en.wikipedia.org/wiki/Phosphodiesterase-5;

Is substance : O;

UNII : EC 3.1.4.35;

Details

Origin ID

D054706;

UMLS CUI

C0757672;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Phosphodiesterase 5a [OMIM gene]
- cGMP-Specific 3',5'-Cyclic Phosphodiesterase [NCIt concept]
- phosphodiesterase 5A [HGNC gene]
- phosphodiesterase i [SNOMED Notion]
- phosphoric diester hydrolase activity [GO term]
Indexing information
- 1-(6-ethoxy-5-(3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo(4,3-d)pyrimidin-5-yl)-3-pyridyl sulphonyl)-4-ethylpiperazine [MeSH Supplementary Concept]
- 3-(4-(2-hydroxyethyl)piperazin-1-yl)-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido(3,4-b)pyrazin-2(1H)-one [MeSH Supplementary Concept]
- BC76 compound [MeSH Supplementary Concept]
- N-(6-aminohexyl)-3-(1-ethyl-3-methyl-7-oxo-6,7-dihydro-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-propoxybenzenesulfonamide [MeSH Supplementary Concept]
- avanafil [MeSH Supplementary Concept]
- methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate [MeSH Supplementary Concept]
Record concept(s)
- cyclic nucleotide phosphodiesterases, type 5 [MeSH concept]
Related MeSH Supplementary Concept(s)
- PDE5 protein, S cerevisiae [MeSH Supplementary Concept]
- PDE5A protein, human [MeSH Supplementary Concept]
- Pde5a protein, mouse [MeSH Supplementary Concept]
- Pde5a protein, rat [MeSH Supplementary Concept]
Related MeSH term(s)
- phosphodiesterase 5 inhibitors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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