" /> protein tyrosine phosphatase, Non-Receptor type 22 - CISMeF





Preferred Label : protein tyrosine phosphatase, Non-Receptor type 22;

MeSH definition : A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.;

MeSH synonym : protein-tyrosine phosphatase lyp; tyrosine protein phosphatase, non-receptor type 22; protein tyrosine phosphatase lyp; tyrosine protein phosphatase, non receptor type 22; PTPase Lyp; Lymphoid Phosphatase; protein tyrosine phosphatase, non receptor type 22; PTPN-22 Protein; PTPN 22 Protein;

MeSH hyponym : Lyp2 PTPase; Lyp1 PTPase; PTPase, Lyp1; PTPase, Lyp2;

MeSH Related Number : Lyp1 PTPase; Lyp2 PTPase; EC 3.1.3.48;

Registry Number MeSH : EC 3.1.3.48;

Related CAS MeSH : EC 3.1.3.48 (Lyp1 PTPase); EC 3.1.3.48 (Lyp2 PTPase);

Is substance : O;

UNII : EC 3.1.3.48;

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A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.

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04/05/2025


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