Preferred Label : protein tyrosine phosphatase, Non-Receptor type 12;
MeSH definition : A subtype of non-receptor protein tyrosine phosphatases that is characterized by the
presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched
in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase
subtype is ubiquitously expressed and implicated in the regulation of a variety of
biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly;
and LYMPHOCYTE ACTIVATION.;
MeSH synonym : ptpase, pep; ptp-pest; PEST-Enriched Phosphatase; pest enriched phosphatase; phosphatase, pest-enriched; pep protein tyrosine phosphatase; PEP PTPase; protein tyrosine phosphatase, non receptor type 12;
Registry Number MeSH : EC 3.1.3.48;
Is substance : O;
UNII : EC 3.1.3.48;
Origin ID : D054594;
UMLS CUI : C0255873;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the
presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched
in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase
subtype is ubiquitously expressed and implicated in the regulation of a variety of
biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly;
and LYMPHOCYTE ACTIVATION.
