lim kinases - CISMeF

Preferred Label : lim kinases;

MeSH definition : Serine protein kinases involved in the regulation of ACTIN polymerization and MICROTUBULE disassembly. Their activity is regulated by phosphorylation of a threonine residue within the activation loop by intracellular signaling kinases such as P21-ACTIVATED KINASES and by RHO KINASE.;

MeSH synonym : kinase, lim; kinases, lim; lim motif containing protein kinases; lim-kinase; LIM Kinase; LIM Motif-Containing Protein Kinases;

Registry Number MeSH : EC 2.7.11.1;

Is substance : O;

UNII : EC 2.7.11.1;

Details

Origin ID

D054461;

UMLS CUI

C0294209;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- LIM Domain Kinase 1 [NCIt concept]
Record concept(s)
- lim kinases [MeSH concept]
Related MeSH Supplementary Concept(s)
- LIMK1 protein, human [MeSH Supplementary Concept]
- LIMK2 protein, human [MeSH Supplementary Concept]
- Limk1 protein, mouse [MeSH Supplementary Concept]
- Limk1 protein, rat [MeSH Supplementary Concept]
- Limk2 protein, mouse [MeSH Supplementary Concept]
- Limk2 protein, rat [MeSH Supplementary Concept]
- Limk2 protein, xenopus [MeSH Supplementary Concept]
- limk1 protein, Drosophila [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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