perforin - CISMeF

Preferred Label : perforin;

MeSH definition : A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.;

MeSH synonym : lymphocyte pore forming protein; lymphocyte pore-forming protein; perforin 1; pore-forming protein, lymphocyte; cytolysin;

Registry Number MeSH : 126465-35-8;

Wikipedia link : https://en.wikipedia.org/wiki/Perforin;

Is substance : O;

Details

Origin ID

D054353;

UMLS CUI

C0070410;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Pharmacological action(s)
- cytotoxins [MeSH Descriptor]
Record concept(s)
- perforin [MeSH concept]
Related MeSH Supplementary Concept(s)
- PRF1 protein, human [MeSH Supplementary Concept]
- perforin 1, mouse [MeSH Supplementary Concept]
- perforin-CEBPD [MeSH Supplementary Concept]
- perforin-granzyme B [MeSH Supplementary Concept]
- perforin-like protein 1, toxoplasma gondii [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Perforin [LOINC component]
- Perforin (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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