Preferred Label : receptors, kir;
MeSH definition : A family of receptors found on NK CELLS that have specificity for a variety of HLA
ANTIGENS. KIR receptors contain up to three different extracellular immunoglobulin-like
domains referred to as D0, D1, and D2 and play an important role in blocking NK cell
activation against cells expressing the appropriate HLA antigens thus preventing cell
lysis. Although they are often referred to as being inhibitory receptors, a subset
of KIR receptors may also play an activating role in NK cells.;
MeSH synonym : immunoglobulin-like receptor, killer; inhibitory receptor, killer; killer cell immunoglobulin like receptor; killer cell immunoglobulin like receptors; killer cell immunoglobulin-like receptors; killer inhibitory receptors; kir receptor; p58 nk cell inhibitory receptor; receptor, killer immunoglobulin-like; receptors, killer inhibitory; receptors, kir family; inhibitory receptors, killer; receptor, p58 nk cell; p58 natural killer cell receptor; receptor, kir; receptor, killer inhibitory; killer inhibitory receptor; killer immunoglobulin-like receptor; killer immunoglobulin like receptor; killer cell immunoglobulin-like receptor; kir family receptors; family receptors, kir; kir receptors; killer immunoglobulin-like receptor (kir) family of receptors; p58 nk cell receptor; p58 nk cell receptors;
MeSH annotation : general; prefer specifics;
Is substance : O;
Origin ID : D054340;
UMLS CUI : C0665952;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
A family of receptors found on NK CELLS that have specificity for a variety of HLA
ANTIGENS. KIR receptors contain up to three different extracellular immunoglobulin-like
domains referred to as D0, D1, and D2 and play an important role in blocking NK cell
activation against cells expressing the appropriate HLA antigens thus preventing cell
lysis. Although they are often referred to as being inhibitory receptors, a subset
of KIR receptors may also play an activating role in NK cells.
