HIV reverse transcriptase

Preferred Label : HIV reverse transcriptase;

MeSH definition : A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.;

MeSH synonym : transcriptase, hiv reverse; reverse transcriptase, hiv; reverse transcriptase, human immunodeficiency virus;

Registry Number MeSH : EC 2.7.7.49;

Is substance : O;

UNII : EC 2.7.7.49;

Details

Origin ID

D054303;

UMLS CUI

C1955880;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Reverse Transcriptase [NCIt concept]
Indexing information
- 1,5-diphenyl-3-(2-hydroxyethyl)-4-ethylpyrazole [MeSH Supplementary Concept]
- 1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine [MeSH Supplementary Concept]
- 1-(2',5'-bis-O-(t-butyldimethylsilyl)ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)-3-ethylthymine [MeSH Supplementary Concept]
- 1-(2',6'-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole [MeSH Supplementary Concept]
- 1-(2-(diphenylmethoxy)ethyl)-2-methyl-5-nitroimidazole [MeSH Supplementary Concept]
- 1-(2-chloro-6-fluorophenyl)-1H,3H-oxazolo(3,4-a)benzimidazole [MeSH Supplementary Concept]
- 1-(4-methoxy-3,5-dimethylbenzyl)-4-(3-(ethylamino)-2-pyridyl)piperazine hydrochloride [MeSH Supplementary Concept]
- 1-phenyl-1H,3H-oxazolo(3,4-a)benzimidazole [MeSH Supplementary Concept]
- 1H,3H-thiazolo(3,4-a)benzimidazole [MeSH Supplementary Concept]
- 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine [MeSH Supplementary Concept]
- 2,2-dimethylthiopropionic acid S-(2-((4-(4-benzyl-3-ethoxymethyl-5-isopropyl-2,6-dioxo-3,6-dihydro-2H-pyrimidine-1-carbonyl)phenoxy)-(5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydrofuran-2-ylmethoxy)phosphoryloxy)ethyl) ester [MeSH Supplementary Concept]
- 2-(difluoro-((4-ethylpyrimidinyl)thio)methyl)benzoxazole [MeSH Supplementary Concept]
- 2-benzoylmethylthio-6-(alpha-cyano-(1-naphthylmethyl))-3,4-dihydro-5-methylpyrimidin-4(3H)-one [MeSH Supplementary Concept]
- 2-chloro-5,11-dihydro-11--ethyl-5-methyl-8-phenylethyl-6H-dipyrido(3,2-b-2',3'-e)(1,4)diazepin-6-one [MeSH Supplementary Concept]
- 2-chloro-5,11-dihydro-11-ethyl-5-methyl-8-(2-(pyridin-4-yl)ethyl)-6H-dipyrido(3,2-b-2',3'-e)(1,4)diazepin-6-one [MeSH Supplementary Concept]
- 2-cyclopentylamino-6-(1-(2,6-difluorophenyl)ethyl)-3,4-dihydro-5-methylpyrimidin-4(3H)-one [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxyadenosine [MeSH Supplementary Concept]
- 3'-azido-2',3'-dideoxycytidine [MeSH Supplementary Concept]
- 3'-deoxy-3'-fluoro-2-thiothymidine 5'-triphosphate [MeSH Supplementary Concept]
- 3'-deoxy-3'-fluoro-4-thiothymidine 5'-triphosphate [MeSH Supplementary Concept]
- 3-(4-(2-methylimidazo(4,5-c)pyridin-1-yl)benzyl)-3H-benzothiazol-2-one [MeSH Supplementary Concept]
- 3-(5-((6-amino-1H-pyrazolo(3,4-b)pyridine-3-yl)methoxy)-2-chlorophenoxy)-5-chlorobenzonitrile [MeSH Supplementary Concept]
- 4-(3-iodophenyl)-3-oxobutanenitrile [MeSH Supplementary Concept]
- 4-chlorophenylhydrazone mesoxalic acid [MeSH Supplementary Concept]
- 4-hydroxy-7-((((5-hydroxy-6-((4-cinnamylphenyl)azo)-7-sulfo-2-naphthalenyl)amino)carbonyl)amino)-3-((4-cinnamylphenyl))azo-2-naphthalenesulfonic acid [MeSH Supplementary Concept]
- 5,2'-dihydroxy-7,3',4',5'-tetramethoxyflavone [MeSH Supplementary Concept]
- 5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone [MeSH Supplementary Concept]
- 5-ethyl-1-(3-(2-furyl)prop-2-en-1-yl)-6-(phenylthio)uracil [MeSH Supplementary Concept]
- 5-ethyl-6-(phenylthio)-1-(3-(2-thienyl)prop-2-en-1-yl)uracil [MeSH Supplementary Concept]
- 5-fluoro-1-(2-hydroxymethyl)-1,3-oxathiolane-5-yl-cytidine-5'-triphosphate [MeSH Supplementary Concept]
- 5-isopropyl-1-((hydroxyethoxy)methyl)-6-(3,5-dimethylphenythio)-2-thiouracil [MeSH Supplementary Concept]
- 5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido(3,2-b)indole-3-carbonitrile [MeSH Supplementary Concept]
- 6-((3,5-dimethylphenyl)thio)-5-ethyl-1-(3-(2-furyl)prop-2-en-1-yl)uracil [MeSH Supplementary Concept]
- 6-(2,6-dichlorobenzyl)-2-(2-(4-methoxyphenyl)ethylthio)-5-methylpyrimdin-4(3H)-one [MeSH Supplementary Concept]
- 6-(alpha-cyanobenzyl)-3,4-dihydro-2-isopropylthio-5-methylpyrimidin-4(3H)-one [MeSH Supplementary Concept]
- 9-aminonevirapine [MeSH Supplementary Concept]
- BM 21.1298 [MeSH Supplementary Concept]
- BM 21.1326 [MeSH Supplementary Concept]
- BM 50.0934 [MeSH Supplementary Concept]
- BM 51.0836 [MeSH Supplementary Concept]
- Dapivirine [MeSH Supplementary Concept]
- L 696229 [MeSH Supplementary Concept]
- L 702007 [MeSH Supplementary Concept]
- MIV 150 [MeSH Supplementary Concept]
- MIV-160 [MeSH Supplementary Concept]
- N-(2-(6-fluoro-2-hydroxy-3-propionylphenyl)cyclopropyl)-N'-(2-(5-bromopyridyl))urea [MeSH Supplementary Concept]
- N-(4-(((4-chloro-2-(3-chloro-5-cyanobenzoyl)phenoxy)acetyl)amino)-3-methylphenyl)sulfonylpropanamide [MeSH Supplementary Concept]
- N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldeyde hydrazone [MeSH Supplementary Concept]
- NNRTI MKC-442 [MeSH Supplementary Concept]
- NSC 615985 [MeSH Supplementary Concept]
- O-methylfagaronine [MeSH Supplementary Concept]
- PETT 1 [MeSH Supplementary Concept]
- PETT 2 [MeSH Supplementary Concept]
- R 157208 [MeSH Supplementary Concept]
- R 165481 [MeSH Supplementary Concept]
- R 221239 [MeSH Supplementary Concept]
- R 86183 [MeSH Supplementary Concept]
- R-82913 [MeSH Supplementary Concept]
- S 2720 [MeSH Supplementary Concept]
- TSAO-T [MeSH Supplementary Concept]
- U 89674 [MeSH Supplementary Concept]
- YM 215389 [MeSH Supplementary Concept]
- YM 228855 [MeSH Supplementary Concept]
- beta-thujaplicinol [MeSH Supplementary Concept]
- coccinin protein, phaseolus coccineus [MeSH Supplementary Concept]
- cordysobin protein, cordyceps sobolifera [MeSH Supplementary Concept]
- dexelvucitabine [MeSH Supplementary Concept]
- ginkbilobin protein, ginkgo biloba [MeSH Supplementary Concept]
- gymnin protein, gymnocladus chinensis [MeSH Supplementary Concept]
- limenin protein, phaseolus limensis [MeSH Supplementary Concept]
- manicol [MeSH Supplementary Concept]
- methyl 2-(aminocarbonyl)-5-chloro-1H-indol-3-yl-(phenyl)phosphinate [MeSH Supplementary Concept]
- phasein A [MeSH Supplementary Concept]
- phasein B [MeSH Supplementary Concept]
- polyacetylenetriol [MeSH Supplementary Concept]
- pyridobenzo(b,f)1,5-oxazocyn-6-one [MeSH Supplementary Concept]
- salaspermic acid [MeSH Supplementary Concept]
- sefavirenz [MeSH Supplementary Concept]
- synadenol triphosphate [MeSH Supplementary Concept]
- trichogin protein, tricholoma giganteum [MeSH Supplementary Concept]
- vulgarinin, phaseolus vulgaris [MeSH Supplementary Concept]
Record concept(s)
- HIV reverse transcriptase [MeSH concept]
Related MeSH Supplementary Concept(s)
- HIV-1 reverse transcriptase (395-404) [MeSH Supplementary Concept]
- reverse transcriptase, human immunodeficiency virus 1 [MeSH Supplementary Concept]
- reverse transcriptase, human immunodeficiency virus 2 [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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