MeSH definition : A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains
which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment
domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE
KINASES. The protein plays a role in the host defense response by signaling the activation
of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the
nucleotide oligomerization domain 2 protein have been associated with increased susceptibility
to CROHN DISEASE.;
A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains
which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment
domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE
KINASES. The protein plays a role in the host defense response by signaling the activation
of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the
nucleotide oligomerization domain 2 protein have been associated with increased susceptibility
to CROHN DISEASE.
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