apolipoprotein e2

Preferred Label : apolipoprotein e2;

MeSH definition : One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.;

MeSH synonym : apoe epsilon 2; apolipoprotein e epsilon2; APOE-epsilon2; apoe epsilon2; ApoE2; APOE-epsilon 2; Apo E-2; apo e 2; Apo E2; apolipoprotein e-epsilon2; apolipoprotein e-2; apolipoprotein e 2;

Is substance : O;

Details

Origin ID

D053329;

UMLS CUI

C0052198;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Apolipoprotein E-II [OBSOLETE LOINC component]
- Apolipoprotein E2 [LOINC component]
- Apolipoprotein E2 (substance) [SNOMED CT concept]
- apolipoprotein e2 [SNOMED Notion]
Record concept(s)
- apolipoprotein E2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- apolipoprotein E2 (Bethesda) [MeSH Supplementary Concept]
- apolipoprotein E2 (Kyoto) [MeSH Supplementary Concept]
- apolipoprotein E2 (Lys146 -- gln) [MeSH Supplementary Concept]
See also inter- (CISMeF)
- APOE*2 Allele [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Apolipoprotein E2 [LOINC component]
- Apolipoprotein E2 (substance) [SNOMED CT concept]
- apolipoprotein e2 [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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