tnf-related apoptosis-inducing ligand

Preferred Label : tnf-related apoptosis-inducing ligand;

MeSH definition : A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.;

MeSH synonym : apo 2 ligand; apoptosis-inducing ligand, tnf-related; tnf superfamily, member 10; trail protein; tumor necrosis factor ligand superfamily member 10; apo-2 ligand; apo-2l protein; apo 2l protein; TNF related apoptosis inducing ligand; CD253 Antigen; Antigen, CD253;

Is substance : O;

Details

Origin ID

D053221;

UMLS CUI

C0385242;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- TNF-Related Apoptosis-Inducing ligand [MeSH concept]
Related MeSH Supplementary Concept(s)
- AD-O53.2 fusion protein [MeSH Supplementary Concept]
- Fn14-TRAIL fusion protein, human [MeSH Supplementary Concept]
- TNFSF10 protein, Xenopus [MeSH Supplementary Concept]
- TNFSF10 protein, human [MeSH Supplementary Concept]
- Tnfsf10 protein, mouse [MeSH Supplementary Concept]
- Tnfsf10 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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