Preferred Label : B7-2 Antigen;
MeSH definition : A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN
with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction
of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its
interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.; A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN.
It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity
and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN
provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4
ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.;
MeSH synonym : b7 2 antigen; b70 costimulatory molecule; costimulatory molecule, b7-2; early t cell costimulatory molecule 1; b7-2 costimulatory molecule; cd86 antigen; antigen, cd86; cd86 antigens; antigen, b7-2; antigen, b7 2; costimulatory molecule, b70; Antigens, CD86;
Wikipedia link : https://en.wikipedia.org/wiki/Cd86 antigens;
Is substance : O;
Origin ID : D051940;
UMLS CUI : C0527903;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN
with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction
of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its
interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
A costimulatory ligand glycoprotein that contains a C2 and V-type IMMUNOGLOBULIN DOMAIN.
It is expressed by ANTIGEN-PRESENTING CELLS and binds to CD28 ANTIGEN with high specificity
and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN
provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4
ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
