von hippel-lindau tumor suppressor protein

Preferred Label : von hippel-lindau tumor suppressor protein;

MeSH definition : A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.;

MeSH synonym : vhl tumor suppressor protein; von hippel lindau tumor suppressor protein;

Registry Number MeSH : EC 6.3.2.19; EC 2.3.2.27;

Is substance : O;

UNII : EC 2.3.2.27;

Details

Origin ID

D051794;

UMLS CUI

C1566585;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- UBE3A wt Allele [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 C [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 D2 [NCIt concept]
- Ubiquitin-Protein Ligase E3A [NCIt concept]
Record concept(s)
- von Hippel-Lindau tumor suppressor protein [MeSH concept]
Related MeSH Supplementary Concept(s)
- VHL protein, human [MeSH Supplementary Concept]
- VHL protein, mouse [MeSH Supplementary Concept]
- VHLL protein, human [MeSH Supplementary Concept]
Related MeSH term(s)
- von Hippel-Lindau disease [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
Validated automatic mappings to BTNT
- Von Hippel-Lindau Disease Tumor Suppressor [NCIt concept]

Keyword's position in hierarchy(ies) :

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