proto-oncogene proteins c-mdm2

Preferred Label : proto-oncogene proteins c-mdm2;

MeSH definition : An E3 UBIQUITIN LIGASE that interacts with and inhibits TUMOR SUPPRESSOR PROTEIN P53. Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF.;

MeSH synonym : murine double minute 2 protein; proto-oncogene protein, c-mdm2; c mdm2 proto oncogene protein; double minute 2 protein; mdmx protein; c-mdm2, proto-oncogene proteins; mdm-2 protein; mdm 2 protein; c-mdm2 proto-oncogene protein; mdm2 protein; proto oncogene proteins c mdm2;

Registry Number MeSH : EC 6.3.2.19; EC 2.3.2.27;

Is substance : O;

UNII : EC 2.3.2.27;

Details

Origin ID

D051736;

UMLS CUI

C0127306;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 2-(5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(2-hydroxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid [MeSH Supplementary Concept]
- ATSP-7041 [MeSH Supplementary Concept]
- MI 319 [MeSH Supplementary Concept]
- MI-291 [MeSH Supplementary Concept]
- MI-888 [MeSH Supplementary Concept]
- PXN822 [MeSH Supplementary Concept]
- RG7388 [MeSH Supplementary Concept]
Record concept(s)
- Proto-Oncogene proteins c-mdm2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- MDM2 protein, Xenopus [MeSH Supplementary Concept]
- MDM2 protein, human [MeSH Supplementary Concept]
- Mdm2 protein, mouse [MeSH Supplementary Concept]
- Mdm2 protein, rat [MeSH Supplementary Concept]
- mdm2 protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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