focal adhesion kinase 1

Preferred Label : focal adhesion kinase 1;

MeSH definition : A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.; A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.;

MeSH synonym : endogenous substrate pp120; focal adhesion associated protein tyrosine kinase pp125fak; p125fak protein; Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK; Protein Tyrosine Kinase 2;

CISMeF synonym : EC 2.7.1.112;

Registry Number MeSH : EC 2.7.10.1; EC 2.7.10.2;

Is substance : O;

UNII : EC 2.7.10.2;

Details

Origin ID

D051417;

UMLS CUI

C0059239;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
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- isolation and purification [MeSH Qualifier]
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- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
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- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Focal Adhesion Kinase 1 [NCIt concept]
Indexing information
- defactinib [MeSH Supplementary Concept]
Record concept(s)
- focal adhesion kinase 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- Fak protein, Drosophila [MeSH Supplementary Concept]
- PTK2 protein, human [MeSH Supplementary Concept]
- Ptk2 protein, mouse [MeSH Supplementary Concept]
- Ptk2 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

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