MeSH definition : A signal transducer and activator of transcription that mediates cellular responses
to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL
CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such
as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID
LEUKEMIA.;
MeSH synonym : transcription factor, stat5; factor, stat5 transcription; stat5 protein; signal transducer and activator of transcription 5;
MeSH hyponym : STAT5a transcription factor; STAT5b transcription factor; Transcription Factor, STAT5b; STAT5beta Protein; STAT5b Protein; Signal Transducer and Activator of Transcription 5B; Transcription Factor, STAT5a; Mammary Gland Factor; Signal Transducer and Activator of Transcription 5A; STAT5alpha Protein; STAT5a Protein; Mammary Gland-Specific Nuclear Factor; Mammary Gland Specific Nuclear Factor;
A signal transducer and activator of transcription that mediates cellular responses
to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL
CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such
as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID
LEUKEMIA.