trpp cation channels

Preferred Label : trpp cation channels;

MeSH definition : A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES.; A subgroup of TRP cation channels that are widely expressed in various cell types. Defects are associated with POLYCYSTIC KIDNEY DISEASES. Polycystin-1 and Polycystin-2 form a heteromeric channel essential for regulation of CILIUM length and fluid-flow mechanosensation by the primary cilium in renal epithelium. Polycystin-2 can also function as a homotetramer and modulates calcium ion release from stimulated RYANODINE RECEPTORS in CARDIOMYOCYTES.;

MeSH synonym : cation channels, trpp; channels, trpp cation; polycystins; Polycystin;

MeSH hyponym : PKD1 Protein; Polycystic Breakpoint (PBP) Protein; Polycystin 1; Autosomal Dominant Polycystic Kidney Disease Type II Protein; PKD2 Protein; Polycystin 2;

Is substance : O;

Details

Origin ID

D050396;

UMLS CUI

C1153432;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- calcium-activated cation channel activity [GO term]
Indexing information
- PKD2L2 protein, human [MeSH Supplementary Concept]
- Pkd2l2 protein, mouse [MeSH Supplementary Concept]
Record concept(s)
- TRPP cation channels [MeSH concept]
- polycystic kidney disease 1 protein [MeSH concept]
- polycystic kidney disease 2 protein [MeSH concept]
Related MeSH Supplementary Concept(s)
- PKD-2 protein, C elegans [MeSH Supplementary Concept]
- PKD1 protein, Xenopus [MeSH Supplementary Concept]
- PKD1 protein, human [MeSH Supplementary Concept]
- PKD1L3 protein, mouse [MeSH Supplementary Concept]
- PKD2 protein, human [MeSH Supplementary Concept]
- PKD2 protein, rat [MeSH Supplementary Concept]
- PKD2 protein, zebrafish [MeSH Supplementary Concept]
- Pkd1 protein, mouse [MeSH Supplementary Concept]
- Pkd1 protein, rat [MeSH Supplementary Concept]
- Pkd2 protein, Drosophila [MeSH Supplementary Concept]
- Pkd2 protein, mouse [MeSH Supplementary Concept]
- polycystic kidney disease 1 protein [MeSH Supplementary Concept]
- polycystic kidney disease 2 protein [MeSH Supplementary Concept]
- polycystin-L, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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