transient receptor potential channels

Preferred Label : transient receptor potential channels;

MeSH definition : A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.;

MeSH synonym : cation channels, trp; channels, trp cation; membrane proteins, trp; proteins, trp membrane; trp cation channels; trp membrane proteins; Transient Receptor Potential Cation Channels; TRP Cation Channel; Cation Channel, TRP; Channel, TRP Cation; Transient Receptor Potential Cation Channel; Transient Receptor Potential Channel;

MeSH annotation : note entry terms: TRP refers to transient receptor potential not TRYPTOPHAN;

Is substance : O;

Details

Origin ID

D050051;

UMLS CUI

C1563722;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- polycystin 1, transient receptor potential channel interacting [HGNC gene]
- polycystin 2 like 1, transient receptor potential cation channel [HGNC gene]
- polycystin 2, transient receptor potential cation channel [HGNC gene]
Indexing information
- 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide [MeSH Supplementary Concept]
- 5H-dibenzo(b,e)azepine-10-carboxylic acid methyl ester [MeSH Supplementary Concept]
- A 967079 [MeSH Supplementary Concept]
- HC-067047 [MeSH Supplementary Concept]
- dibenzo(b,f)(1,4)oxazepine-4-carboxylic acid methyl ester [MeSH Supplementary Concept]
Record concept(s)
- transient receptor potential channels [MeSH concept]
Related MeSH Supplementary Concept(s)
- LOC100492885 protein, Xenopus [MeSH Supplementary Concept]
- MCOLN1 protein, human [MeSH Supplementary Concept]
- MCOLN3 protein, human [MeSH Supplementary Concept]
- Mcoln1 protein, mouse [MeSH Supplementary Concept]
- Mcoln1 protein, rat [MeSH Supplementary Concept]
- Mcoln2 protein, human [MeSH Supplementary Concept]
- Mcoln2 protein, mouse [MeSH Supplementary Concept]
- Mcoln3 protein, mouse [MeSH Supplementary Concept]
- NOMPC protein, drosophila [MeSH Supplementary Concept]
- Nan protein, Drosophila [MeSH Supplementary Concept]
- Pkd2p protein, S pombe [MeSH Supplementary Concept]
- Pyx-PB protein, Drosophila [MeSH Supplementary Concept]
- TRPA1 protein, human [MeSH Supplementary Concept]
- TRPML protein, drosophila [MeSH Supplementary Concept]
- TRPgamma protein, drosophila [MeSH Supplementary Concept]
- Trpa1 protein, mouse [MeSH Supplementary Concept]
- brv1 protein, Drosophila [MeSH Supplementary Concept]
- mcoln1a protein, zebrafish [MeSH Supplementary Concept]
- mucoln 1.2 protein, danio rerio [MeSH Supplementary Concept]
- pyx protein, Drosophila [MeSH Supplementary Concept]
- trp protein, drosophila [MeSH Supplementary Concept]
- trpa-1 protein, C elegans [MeSH Supplementary Concept]
- trpa1a protein, zebrafish [MeSH Supplementary Concept]
- trpl protein, drosophila [MeSH Supplementary Concept]
- trpn1 protein, zebrafish [MeSH Supplementary Concept]
- wtrw protein, Drosophila [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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