Preferred Label : transient receptor potential channels;
MeSH definition : A broad group of eukaryotic six-transmembrane cation channels that are classified
by sequence homology because their functional involvement with SENSATION is varied.
They have only weak voltage sensitivity and ion selectivity. They are named after
a DROSOPHILA mutant that displayed transient receptor potentials in response to light.
A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found
in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups.
Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.;
MeSH synonym : cation channels, trp; channels, trp cation; membrane proteins, trp; proteins, trp membrane; trp cation channels; trp membrane proteins; Transient Receptor Potential Cation Channels; TRP Cation Channel; Cation Channel, TRP; Channel, TRP Cation; Transient Receptor Potential Cation Channel; Transient Receptor Potential Channel;
MeSH annotation : note entry terms: TRP refers to transient receptor potential not TRYPTOPHAN;
Is substance : O;
Origin ID : D050051;
UMLS CUI : C1563722;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A broad group of eukaryotic six-transmembrane cation channels that are classified
by sequence homology because their functional involvement with SENSATION is varied.
They have only weak voltage sensitivity and ion selectivity. They are named after
a DROSOPHILA mutant that displayed transient receptor potentials in response to light.
A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found
in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups.
Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
