MAP kinase kinase 4

Preferred Label : MAP kinase kinase 4;

MeSH definition : A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.;

MeSH synonym : jn kinase kinase; jnk activating protein kinase; jnkk1 protein kinase; jun amino-terminal kinase kinase; mitogen-activated protein kinase kinase 4; sap kinase extracellular signal regulated kinase kinase 1; sap kinase kinase 1; sek1 protein kinase; stress-activated protein kinase kinase 1; jnk kinase; jnk-activating protein kinase; protein kinase, jnk-activating; kinase, jnkk1 protein; protein kinase, jnkk1; jun amino terminal kinase kinase; stress activated protein kinase kinase 1; mitogen activated protein kinase kinase 4; sap kinase-extracellular signal-regulated kinase kinase 1; sapk-erk kinase 1; sapk erk kinase 1; protein kinase, sek1; mek4 protein kinase; protein kinase, mek4;

CISMeF synonym : EC 2.7.1.-;

Registry Number MeSH : EC 2.7.12.2;

Is substance : O;

UNII : EC 2.7.12.2;

Details

Origin ID

D048670;

UMLS CUI

C0291988;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- Mitogen-activated protein kinase kinase 4 [OMIM gene]
- mitogen-activated protein kinase kinase 4 [HGNC gene]
Indexing information
- CC-359 [MeSH Supplementary Concept]
- SR9444 [MeSH Supplementary Concept]
Record concept(s)
- MAP kinase kinase 4 [MeSH concept]
Related MeSH Supplementary Concept(s)
- MAP2K4 protein, human [MeSH Supplementary Concept]
- Map2k4 protein, mouse [MeSH Supplementary Concept]
- sek-1 protein, C elegans [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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