flap endonucleases

Preferred Label : flap endonucleases;

MeSH definition : Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.;

MeSH synonym : endonucleases, flap; Flap Endonuclease; Endonuclease, Flap;

MeSH hyponym : flap Endonuclease-1; Endonuclease-1, Flap; Flap Endonuclease 1; RTH-1 Nuclease; Nuclease, RTH-1; RTH 1 Nuclease; RAD2 Homolog-1 Nuclease; RAD2 Homolog 1 Nuclease; FEN-1; Fen1 Protein;

Registry Number MeSH : EC 3.1.-;

Is substance : O;

Details

Origin ID

D045585;

UMLS CUI

C1257113;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Esterase [NCIt concept]
- FEN1 Gene [NCIt concept]
- FEN1 wt Allele [NCIt concept]
- Flap Endonuclease 1 [NCIt concept]
- Flap structure-specific endonuclease 1 [OMIM gene]
- Protein Artemis [NCIt concept]
Record concept(s)
- flap Endonuclease-1 [MeSH concept]
- flap endonucleases [MeSH concept]
Related MeSH Supplementary Concept(s)
- Dna2 protein, S pombe [MeSH Supplementary Concept]
- FEN1 protein, human [MeSH Supplementary Concept]
- Fen1 protein, mouse [MeSH Supplementary Concept]
- Fen1 protein, rat [MeSH Supplementary Concept]
- MMS4 protein, S cerevisiae [MeSH Supplementary Concept]
- RAD27 protein, S cerevisiae [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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