alpha-Mannosidase

Preferred Label : alpha-Mannosidase;

MeSH definition : An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.;

MeSH synonym : mannohydrolase, alpha-d-mannoside; alpha d mannosidase; alpha-d-mannoside mannohydrolase; alpha d mannoside mannohydrolase; neutral alpha-mannosidase; neutral alpha mannosidase; alpha-mannosidase, neutral; alpha-d-mannosidase; alpha mannosidase;

MeSH hyponym : lysosomal alpha-Mannosidase; Lysosomal alpha Mannosidase; alpha-Mannosidase, Lysosomal; LAMAN; alpha Mannosidase B; Mannosidase B, alpha;

MeSH Related Number : lysosomal alpha-Mannosidase; EC 3.2.1.24;

Registry Number MeSH : EC 3.2.1.24;

Related CAS MeSH : EC 3.2.1.24 (Lysosomal alpha-Mannosidase);

MeSH annotation : /DEFIC: consider also ALPHA-MANNOSIDOSIS;

Is substance : O;

UNII : EC 3.2.1.24;

Details

Origin ID

D043323;

UMLS CUI

C0051350;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- 5-amino-3-hydroxycyclopentane-1,2-diol [MeSH Supplementary Concept]
Record concept(s)
- alpha-Mannosidase [MeSH concept]
- lysosomal alpha-Mannosidase [MeSH concept]
Related MeSH Supplementary Concept(s)
- AMS1 protein, S cerevisiae [MeSH Supplementary Concept]
- EDEM2 protein, human [MeSH Supplementary Concept]
- EDEM3 protein, human [MeSH Supplementary Concept]
- EDEM3 protein, mouse [MeSH Supplementary Concept]
- Edem2 protein, mouse [MeSH Supplementary Concept]
- MAN2A1 protein, rat [MeSH Supplementary Concept]
- MAN2A1-FER fusion protein, human [MeSH Supplementary Concept]
- MAN2B1 protein, rat [MeSH Supplementary Concept]
- MAN2C1 protein, human [MeSH Supplementary Concept]
- MNS1 protein, Arabidopsis [MeSH Supplementary Concept]
- MNS2 protein, Arabidopsis [MeSH Supplementary Concept]
- Man2c1 protein, mouse [MeSH Supplementary Concept]
See also
- alpha-Mannosidosis [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Alpha mannosidase [LOINC component]
- Alpha-mannosidase (substance) [SNOMED CT concept]
- alpha-mannosidase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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