11-beta-Hydroxysteroid dehydrogenase type 2

Preferred Label : 11-beta-Hydroxysteroid dehydrogenase type 2;

MeSH definition : An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.;

MeSH synonym : 11beta-hydroxysteroid dehydrogenase type 2; 11beta-hsd2; 11beta-hsd2 reductase; 11beta hydroxysteroid dehydrogenase type 2; 11 beta-hsd2; 11 beta-Hydroxysteroid dehydrogenase type 2; 11 beta hydroxysteroid dehydrogenase type 2;

Registry Number MeSH : EC 1.1.1.146;

Wikipedia link : https://en.wikipedia.org/wiki/11-beta-Hydroxysteroid dehydrogenase type 2;

Is substance : O;

UNII : EC 1.1.1.146;

Details

Origin ID

D043209;

UMLS CUI

C0608861;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- 11-beta-Hydroxysteroid dehydrogenase type 2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- HSD11B2 protein, human [MeSH Supplementary Concept]
- HSD11B2 protein, mouse [MeSH Supplementary Concept]
- Hsd11b2 protein, rat [MeSH Supplementary Concept]
Related MeSH term(s)
- mineralocorticoid excess syndrome, apparent [MeSH Descriptor]
See also inter- (CISMeF)
- 11 Beta-Hydroxysteroid Dehydrogenase Type 2 Deficiency [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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