Cytochrome-B(5) reductase

Preferred Label : Cytochrome-B(5) reductase;

MeSH definition : A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.;

MeSH synonym : nadh cytochrome b5 reductase; nadh-cytochrome b5 reductase; b5 reductase, nadh-cytochrome;

MeSH hyponym : methemoglobin reductase; Reductase, Methemoglobin; NADH-Ferrihemoglobin Reductase; NADH Ferrihemoglobin Reductase; Reductase, NADH-Ferrihemoglobin; NADH Methemoglobin Reductase; Methemoglobin Reductase, NADH; Reductase, NADH Methemoglobin;

CISMeF hyponym : EC 1.6.2.2;

MeSH Related Number : methemoglobin reductase; 9032-25-1 (CRN); EC 1.6.2.2;

Registry Number MeSH : EC 1.6.2.2;

Related CAS MeSH : EC 1.6.2.2 (Methemoglobin reductase);

MeSH annotation : /defic: consider also METHEMOGLOBINEMIA;

Is substance : O;

UNII : EC 1.6.2.2;

Details

Origin ID

D042966;

UMLS CUI

C0056921;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Biliverdin reductase b [OMIM gene]
- NADH methemoglobin reductase [OBSOLETE LOINC component]
Currated CISMeF NLP mapping
- Cytochrome B5 reductase [LOINC component]
- Cytochrome-b>5< reductase (substance) [SNOMED CT concept]
- cytochrome-b5 reductase [SNOMED Notion]
Record concept(s)
- Cytochrome-B(5) reductase [MeSH concept]
- methemoglobin reductase [MeSH concept]
Related MeSH Supplementary Concept(s)
- CBR1 protein, Arabidopsis [MeSH Supplementary Concept]
- CYB5R1 protein, human [MeSH Supplementary Concept]
- CYB5R2 protein, human [MeSH Supplementary Concept]
- CYB5R3 protein, human [MeSH Supplementary Concept]
- Cyb5R3 protein, rat [MeSH Supplementary Concept]
- Cyb5r3 protein, mouse [MeSH Supplementary Concept]
- MCR1 protein, S cerevisiae [MeSH Supplementary Concept]
- NADH cytochrome B5 reductase deficiency [MeSH Supplementary Concept]
- Ncb5or protein, mouse [MeSH Supplementary Concept]
- methemoglobin reductase deficiency [MeSH Supplementary Concept]
See also (suggested by CISMeF)
- methemoglobinemia [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Cytochrome B5 reductase [LOINC component]
- Cytochrome-b>5< reductase (substance) [SNOMED CT concept]
- cytochrome-b5 reductase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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