Preferred Label : semaphorins;
MeSH definition : A family of proteins that mediate axonal guidance. Semaphorins act as repulsive cues
for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different
molecules have been described and divided into eight classes based on domain organization
and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate,
and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane
(classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess
a common 500-amino acid extracellular domain which is critical for receptor binding
and specificity, and is also found in plexins and scatter factor receptors. Their
C termini are class-specific and may contain additional sequence motifs.;
MeSH synonym : semaphorin;
CISMeF synonym : V semaphorins, class;
MeSH hyponym : class 5 semaphorins; class 6 semaphorins; class 4 semaphorins; class 1 semaphorins; class 3 semaphorins; class 7 semaphorins; class V semaphorins; class 2 semaphorins; Semaphorins, Class 2; Semaphorin-2; Semaphorin 2; Semaphorins, Class 3; Semaphorin-3; Semaphorin 3; Semaphorins, Class V; Semaphorin-V; Semaphorin V; Semaphorins, Class 5; Semaphorin-5; Semaphorin 5; Semaphorins, Class 6; Semaphorin-6; Semaphorin 6; Semaphorins, Class 7; Semaphorin-7; Semaphorin 7; Semaphorins, Class 1; Sema 1; Semaphorin-1; Semaphorin 1; Semaphorins, Class 4; Semaphorin-4; Semaphorin 4;
Wikipedia link : https://en.wikipedia.org/wiki/Semaphorins;
Is substance : O;
Origin ID : D039961;
UMLS CUI : C1136340;
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A family of proteins that mediate axonal guidance. Semaphorins act as repulsive cues
for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different
molecules have been described and divided into eight classes based on domain organization
and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate,
and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane
(classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess
a common 500-amino acid extracellular domain which is critical for receptor binding
and specificity, and is also found in plexins and scatter factor receptors. Their
C termini are class-specific and may contain additional sequence motifs.
