neural cell adhesion molecule L1

Preferred Label : neural cell adhesion molecule L1;

MeSH definition : A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.;

MeSH synonym : cell adhesion molecule l1; f11 glycoprotein; glycoprotein, nile; nerve growth factor inducible large external glycoprotein; ngf inducible glycoprotein; ngf-inducible glycoprotein; nile glycoprotein; nerve growth factor-inducible large external glycoprotein; call protein; caml1 gene product; l1cam; nile protein; cell surface glycoprotein l1; neural adhesion molecule l1; glycoprotein, ngf-inducible; l1 cell adhesion molecule;

Is substance : O;

Details

Origin ID

D039842;

UMLS CUI

C0950625;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
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Record concept(s)
- neural cell adhesion molecule L1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- L1CAM protein, human [MeSH Supplementary Concept]
- L1cam protein, mouse [MeSH Supplementary Concept]
- LAD-2 protein, C elegans [MeSH Supplementary Concept]
- NCAM2 protein, human [MeSH Supplementary Concept]
- avian glycoprotein 50-kDa [MeSH Supplementary Concept]
- polysialyl neural cell adhesion molecule [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Neural Cell Adhesion Molecule L1 [NCIt concept]

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