integrin alpha2beta1

Preferred Label : integrin alpha2beta1;

MeSH definition : An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.;

MeSH synonym : alpha2beta1, integrin; alpha2beta1integrin; cd49b cd29; glycoprotein ia iia; glycoprotein ia-iia; late antigen-2, very; platelet membrane glycoprotein heterodimer ia iia; very late antigen 2; very late antigen-2; vla 2; vla-2; cd49b-cd29; platelet membrane glycoprotein heterodimer ia-iia;

Is substance : O;

Details

Origin ID

D038982;

UMLS CUI

C0056111;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- ITGA2 wt Allele [NCIt concept]
Record concept(s)
- integrin alpha2beta1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- type I collagen receptor [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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