RNA-Binding protein FUS

Preferred Label : RNA-Binding protein FUS;

MeSH definition : A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.;

MeSH synonym : fus protein; fus rna-binding protein; pomp75 protein; tls protein; hnrnp p2; translocated in liposarcoma protein; fus rna binding protein; fusion protein in myxoid liposarcoma; RNA-Binding protein, FUS; RNA binding protein FUS;

Is substance : O;

Details

Origin ID

D034702;

UMLS CUI

C0950472;

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Currated CISMeF NLP mapping
- RNA-Binding Protein FUS [NCIt concept]
Record concept(s)
- RNA-Binding protein FUS [MeSH concept]
Related MeSH Supplementary Concept(s)
- FUS protein, human [MeSH Supplementary Concept]
- FUS protein, mouse [MeSH Supplementary Concept]
- FUST-1 protein, C elegans [MeSH Supplementary Concept]
- TLS-CHOP fusion protein, human [MeSH Supplementary Concept]
- TLS-ERG fusion protein, human [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

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