Preferred Label : activin receptors;
MeSH definition : Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE
KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors
also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the
TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of
two different but related protein kinases, Type I and Type II. Activins initiate cellular
signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS,
TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS,
TYPE I ) with subsequent activation of the type I kinase activity.;
MeSH synonym : activin receptor; activin receptor like kinase; activin receptor like kinases; receptor, activin; receptor-like kinase, activin; activin receptor-like kinases; kinases, activin receptor-like; receptor-like kinases, activin; activin receptor-like kinase; kinase, activin receptor-like; Receptors, Activin;
CISMeF synonym : EC 2.7.1.37;
Registry Number MeSH : EC 2.7.11.30;
Wikipedia link : https://en.wikipedia.org/wiki/Activin receptors;
Is substance : O;
UNII : EC 2.7.11.30;
Origin ID : D029404;
UMLS CUI : C0101389;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE
KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors
also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the
TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of
two different but related protein kinases, Type I and Type II. Activins initiate cellular
signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS,
TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS,
TYPE I ) with subsequent activation of the type I kinase activity.
