MeSH definition : Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL
and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once
inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and
dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN
are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING
PROTEIN causes release of karyopherin beta.;
Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL
and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once
inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and
dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN
are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING
PROTEIN causes release of karyopherin beta.
Allowable qualifiers