alpha karyopherins

Preferred Label : alpha karyopherins;

MeSH definition : Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.;

MeSH synonym : karyopherins, alpha; nls-binding protein; nuclear localization sequence receptor; receptor, nls; karyopherin alpha; nuclear localization signal-binding protein; nlsbp; importin-alpha; nls receptor;

Is substance : O;

Details

Origin ID

D028901;

UMLS CUI

C0288912;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- obsolete importin, alpha-subunit [GO term]
Record concept(s)
- alpha karyopherins [MeSH concept]
Related MeSH Supplementary Concept(s)
- Cut15 protein, S pombe [MeSH Supplementary Concept]
- Imp1 protein, S pombe [MeSH Supplementary Concept]
- KPNA1 protein, human [MeSH Supplementary Concept]
- KPNA1 protein, mouse [MeSH Supplementary Concept]
- KPNA2 protein, human [MeSH Supplementary Concept]
- KPNA3 protein, human [MeSH Supplementary Concept]
- KPNA4 protein, human [MeSH Supplementary Concept]
- KPNA5 protein, human [MeSH Supplementary Concept]
- KPNA6 protein, human [MeSH Supplementary Concept]
- KPNA6 protein, mouse [MeSH Supplementary Concept]
- KPNA7 protein, human [MeSH Supplementary Concept]
- Kap-alpha3 protein, drosophila [MeSH Supplementary Concept]
- Kpna2 protein, mouse [MeSH Supplementary Concept]
- Kpna6 protein, rat [MeSH Supplementary Concept]
- Kpna7 protein, mouse [MeSH Supplementary Concept]
- PKL-1c peptide [MeSH Supplementary Concept]
- importin alpha 3, mouse [MeSH Supplementary Concept]
- importin alpha4, mouse [MeSH Supplementary Concept]
- karyopherin alpha 2 [MeSH Supplementary Concept]
See also
- nuclear localization signals [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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