DNA topoisomerase IV

Preferred Label : DNA topoisomerase IV;

MeSH definition : A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.;

MeSH synonym : topoisomerase iv; topoisomerase iv, dna; topo iv;

MeSH hyponym : parC protein; parE protein; parC Gene Product, Topo IV; Topoisomerase IV Subunit A; parC Gene Product; parE Gene Product, Topo IV; Topoisomerase IV Subunit B; parE Gene Product;

MeSH Related Number : parE protein; parC protein;

Registry Number MeSH : EC 5.99.1.-;

Related CAS MeSH : EC 5.99.1.- (parC protein); EC 5.99.1.- (parE protein);

Is substance : O;

Details

Origin ID

D027101;

UMLS CUI

C0082329;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
False automatic mappings
- Topoisomerase IV [NCIt concept]
Indexing information
- 2-(3',4'-dihydroxyphenyl)-5,7-dihydroxy-3-(2'',6''-di-O-(3'''-(4-fluorophenylpropanoyl)))galactosyl-4H-chromen-4-one [MeSH Supplementary Concept]
- 3-amino-7-(3-(1-aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione [MeSH Supplementary Concept]
- 7-(3-(1-aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-1H-quinazoline-2,4-dione [MeSH Supplementary Concept]
- kibdelomycin A [MeSH Supplementary Concept]
Record concept(s)
- DNA topoisomerase IV [MeSH concept]
- parC protein [MeSH concept]
- parE protein [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Topoisomerase IV [NCIt concept]

Keyword's position in hierarchy(ies) :

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