Preferred Label : DNA gyrase;
MeSH definition : A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands
of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken
strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits.
In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex
into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.;
MeSH synonym : DNA-Gyrase;
CISMeF synonym : gyrA gene product; gyrB gene product;
MeSH hyponym : DNA gyrase B subunit; DNA gyrase A subunit; GyrB Protein; GyrA Protein;
Registry Number MeSH : EC 5.99.1.-; EC 5.99.1.3;
Is substance : O;
UNII : EC 5.99.1.3;
Origin ID : D027081;
UMLS CUI : C0949782;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Indexing information
- 1,3,4,5,6,7,8,10-octahydro-14-hydroxy-12-methoxy-11-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-6-thioxo-9,2,5-benzoxanthiaazacyclododecine-10-one [MeSH Supplementary Concept]
- 1,3,4,5,6,7,8,9,10,12-decahydro-16-hydroxy-14-methoxy-13-methyl-4-(3-methyl-1,2,4-oxadiazol-5-yl)-6-thioxo-11,2,5-benzoxathiaazacyclotetradecine-12-one [MeSH Supplementary Concept]
- ACH 702 [MeSH Supplementary Concept]
- Record concept(s)
- Related MeSH term(s)
- Semantic type(s)
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands
of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken
strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits.
In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex
into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
