immunophilins - CISMeF

Preferred Label : immunophilins;

MeSH definition : Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.;

MeSH synonym : Immunophilin;

Related MeSH term : neurophilins; Neurophilin;

MeSH Related Number : neurophilins; EC 5.2.1.8;

Registry Number MeSH : EC 5.2.1.8;

Related CAS MeSH : EC 5.2.1.8 (Neurophilins);

MeSH annotation : don't confuse X ref NEUROPHILINS with NEUROPILINS; don't confuse entry term NEUROPHILINS with NEUROPILINS;

Wikipedia link : https://en.wikipedia.org/wiki/Immunophilins;

Is substance : O;

UNII : EC 5.2.1.8;

Details

Origin ID

D020104;

UMLS CUI

C0600486;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Serine/Threonine-Protein Phosphatase 2A Activator [NCIt concept]
- obsolete immunophilin [GO term]
- peptidyl-prolyl cis-trans isomerase activity [GO term]
Record concept(s)
- immunophilins [MeSH concept]
- neurophilins [MeSH concept]
Related MeSH Supplementary Concept(s)
- AD-01 peptide [MeSH Supplementary Concept]
- FKB-6 protein, C elegans [MeSH Supplementary Concept]
- FKBPL protein, human [MeSH Supplementary Concept]
- FPR3 protein, S cerevisiae [MeSH Supplementary Concept]
- ML1 protein, Burkholderia pseudomallei [MeSH Supplementary Concept]
- TLP40 protein, plant [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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