N-Acetylgalactosamine-4-Sulfatase

Preferred Label : N-Acetylgalactosamine-4-Sulfatase;

MeSH definition : An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.;

MeSH synonym : sulphatase, n-acetylgalactosamine-4-sulphate; n-acetylgalactosamine-4-sulphate sulphatase; 4-sulfatase, n-acetylgalactosamine; n acetylgalactosamine 4 sulphate sulphatase; n-acetylgalactosamine-4-sulfate sulfatase; n acetylgalactosamine 4 sulfate sulfatase; sulfatase, n-acetylgalactosamine-4-sulfate; arylsulfatase b; N-Acetylgalactosamine 4-Sulfatase; N acetylgalactosamine 4 sulfatase;

CISMeF synonym : b, arylsulfatase;

MeSH hyponym : arylsulfatase B1; arylsulfatase B2; B2, Arylsulfatase; B1, Arylsulfatase;

MeSH CAS label : N-Acetyl-D-Galactosamine-4-sulfate 4-sulfohydrolase;

Registry Number MeSH : EC 3.1.6.12;

Is substance : O;

UNII : EC 3.1.6.12;

Details

Origin ID

D020051;

UMLS CUI

C0376159;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Galsulfase [SMS substance]
- Galsulfase [NCIt concept]
- Galsulfase [ICD-11 Extension code]
- Galsulfase (substance) [SNOMED CT concept]
- N-acetylgalactosamine-4-sulfatase (substance) [SNOMED CT concept]
- n-acetylgalactosamine-4-sulfatase [SNOMED Notion]
Record concept(s)
- N-Acetylgalactosamine-4-Sulfatase [MeSH concept]
- arylsulfatase B1 [MeSH concept]
- arylsulfatase B2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- ARSB protein, human [MeSH Supplementary Concept]
- galsulfase [MeSH Supplementary Concept]
Related MeSH term(s)
- mucopolysaccharidosis VI [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- N-Acetylgalactosamine-4-Sulfatase [LOINC component]
- N-acetylgalactosamine-4-sulfatase (substance) [SNOMED CT concept]
- n-acetylgalactosamine-4-sulfatase [SNOMED Notion]

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