Mitogen-Activated protein kinase 1

Preferred Label : Mitogen-Activated protein kinase 1;

MeSH definition : A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.;

MeSH synonym : extracellular signal regulated kinase 2; mapk1 mitogen activated protein kinase; mapk2 mitogen activated protein kinase; mitogen activated protein kinase 2; p42 map kinase; p42(mapk); mitogen-activated protein kinase 2; map kinase 2; mapk1 mitogen-activated protein kinase; mapk2 mitogen-activated protein kinase; p42(mitogen-activated protein kinase); map kinase, p42; p42 mapk; p42(mapk) kinase; extracellular signal-regulated kinase 2; mitogen activated protein kinase 1;

CISMeF synonym : p40 mitogen activated protein kinase; p41 mapk; p41 mitogen-activated protein kinase; EC 2.7.1.37; erk2 brain kinase pk40; p40 mitogen-activated protein kinase; p41 mitogen activated protein kinase;

Registry Number MeSH : EC 2.7.11.24;

MeSH annotation : Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases;

Is substance : O;

UNII : EC 2.7.11.24;

Details

Origin ID

D019950;

UMLS CUI

C0170168;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- MAP kinase activity [GO term]
- MAPK1 wt Allele [NCIt concept]
- Mitogen-activated protein kinase 1 [OMIM gene]
- Serine/Threonine-Protein Kinase NLK [NCIt concept]
- mitogen-activated protein kinase 1 [HGNC gene]
- mitogen-activated protein kinase 1 [ORDO Gene]
Indexing information
- FR 180204 [MeSH Supplementary Concept]
- N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide [MeSH Supplementary Concept]
Record concept(s)
- Mitogen-Activated protein kinase 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- MAPK1 protein, human [MeSH Supplementary Concept]
- Mapk1 protein, mouse [MeSH Supplementary Concept]
- Mapk1 protein, rat [MeSH Supplementary Concept]
- mpk-1 protein, C elegans [MeSH Supplementary Concept]
- p42 MAP kinase, xenopus [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
Validated automatic mappings to BTNT
- Mitogen-Activated Protein Kinase 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients