clavulanic acid

Preferred Label : clavulanic acid;

MeSH definition : Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.; A beta-lactam antibiotic produced by the actinobacterium Streptomyces clavuligerus. It is a suicide inhibitor of bacterial beta-lactamase enzymes. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.;

CISMeF synonym : 57943-81-4 (Clavulanic acid, monosodium salt); 61177-45-5 (Clavulanate potassium);

MeSH hyponym : BRL-14151; clavulanate; clavulanic acid, monosodium salt; MM-14151; clavulanate potassium; MM 14151; MM14151; Potassium, Clavulanate; Potassium Clavulanate; Clavulanate, Potassium; Clavulanic Acid, Monopotassium Salt; Sodium Clavulanate; Clavulanate, Sodium; BRL 14151; BRL14151;

MeSH CAS label : 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha));

MeSH Related Number : clavulanic acid, monosodium salt; clavulanate potassium; 57943-81-4 (mono-Na-salt); 58001-44-8 (Clavulanic acid); 61177-45-5 (mono-K-salt); clavulanate; 85A8F32FMG; Q42OMW3AT8;

Registry Number MeSH : 58001-44-8;

Related CAS MeSH : 23521W1S24 (Clavulanate); 85A8F32FMG (Clavulanic acid, monosodium salt); Q42OMW3AT8 (Clavulanate potassium);

Wikipedia link : https://en.wikipedia.org/wiki/Clavulanic acid;

Codes EINECS : 261-069-2;

Is substance : O;

UNII : 23521W1S24;

InChIKey : HZZVJAQRINQKSD-PBFISZAISA-N;

Details

Origin ID

D019818;

UMLS CUI

C0055860;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- clavulanic acid [Substance BNPC]
Pharmacological action(s)
- beta-Lactamase Inhibitors [MeSH Descriptor]
Record concept(s)
- BRL-14151 [MeSH concept]
- MM-14151 [MeSH concept]
- clavulanate [MeSH concept]
- clavulanate potassium [MeSH concept]
- clavulanic acid [MeSH concept]
- clavulanic acid, monosodium salt [MeSH concept]
Related MeSH Supplementary Concept(s)
- cefotaxime-clavulanic acid drug combination [MeSH Supplementary Concept]
- ceftazidime-clavulanic acid drug combination [MeSH Supplementary Concept]
Related MeSH term(s)
- clavulanic acids [MeSH Descriptor]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
Validated automatic mappings to BTNT
- Potassium clavulanate [SMS substance]

Keyword's position in hierarchy(ies) :

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