Preferred Label : thrombospondins;
MeSH definition : A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated
into the extracellular matrix of a variety of cells, including alpha granules of platelets
following thrombin activation and endothelial cells. They interact with a number of
BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been
identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein
(COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation,
angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.;
MeSH synonym : thrombospondin;
MeSH annotation : membrane glycoproteins; THROMBOSPONDIN 1 is also available;
Wikipedia link : https://en.wikipedia.org/wiki/Thrombospondin;
Is substance : O;
Origin ID : D019699;
UMLS CUI : C0076560;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- Related MeSH Supplementary Concept(s)
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- UMLS correspondences (same concept)
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated
into the extracellular matrix of a variety of cells, including alpha granules of platelets
following thrombin activation and endothelial cells. They interact with a number of
BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been
identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein
(COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation,
angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
