12-hydroxy-5,8,10,14-eicosatetraenoic acid

Preferred Label : 12-hydroxy-5,8,10,14-eicosatetraenoic acid;

MeSH definition : A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51);

MeSH synonym : 12-hete;

MeSH hyponym : 12-R-HETE; 12-S-HETE; 12-S-Hydroxyeicosatetraenoic Acid; 12 S Hydroxyeicosatetraenoic Acid; Acid, 12-S-Hydroxyeicosatetraenoic;

Registry Number MeSH : 59985-28-3;

MeSH annotation : DF: note short X ref;

Is substance : O;

Details

Origin ID

D019377;

UMLS CUI

C0044800;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid [NCIt concept]
Indexing information
- N-(20-hydroxyeicosa-5,14-dienoyl)glycine [MeSH Supplementary Concept]
Record concept(s)
- 12-Hydroxy-5,8,10,14-eicosatetraenoic acid [MeSH concept]
- 12-R-HETE [MeSH concept]
- 12-S-HETE [MeSH concept]
Related MeSH Supplementary Concept(s)
- 12,13-dihydroxy-5,8,10,14-eicosatetraenoic acid [MeSH Supplementary Concept]
- 12,20-dihydroxy-5,8,10,14-eicosatetraenoic acid [MeSH Supplementary Concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid [NCIt concept]

Keyword's position in hierarchy(ies) :

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