Preferred Label : BRCA1 protein;
MeSH definition : The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1
protein is localized in the nucleus, whereas in the majority of breast cancer cell
lines and in malignant pleural effusions from breast cancer patients, it is localized
mainly in the cytoplasm. (Science 1995;270(5237):713,789-91); The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal
RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells
the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer
cell lines and in malignant pleural effusions from breast cancer patients, it is localized
mainly in the cytoplasm. (Science 1995;270(5237):713,789-91);
MeSH synonym : breast cancer 1 gene product; brca1 gene product; breast cancer 1 protein; Breast Cancer Type 1 Susceptibility Protein; Ring Finger Protein 53;
Wikipedia link : https://en.wikipedia.org/wiki/Brca1 protein;
Is substance : O;
Origin ID : D019313;
UMLS CUI : C0259275;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Record concept(s)
- Related MeSH Supplementary Concept(s)
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The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1
protein is localized in the nucleus, whereas in the majority of breast cancer cell
lines and in malignant pleural effusions from breast cancer patients, it is localized
mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal
RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells
the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer
cell lines and in malignant pleural effusions from breast cancer patients, it is localized
mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
