Preferred Label : helix-turn-helix motifs;
MeSH definition : The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were
originally identified in bacterial proteins but have since been found in hundreds
of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed
from two alpha helices connected by a short extended chain of amino acids, which constitute
the turn. The two helices are held at a fixed angle, primarily through interactions
between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed,
p408-9);
MeSH synonym : motif, helix-turn-helix; motifs, hth; helix-turn-helix motif; hth motifs; hth motif; motif, hth; motifs, helix-turn-helix; motifs, helix turn helix; helix turn helix motifs;
MeSH annotation : do not confuse with HELIX-LOOP-HELIX MOTIFS;
Origin ID : D019077;
UMLS CUI : C0282642;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Indexing information
- Ne pas confondre avec
- Record concept(s)
- See also
- See also (suggested by CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were
originally identified in bacterial proteins but have since been found in hundreds
of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed
from two alpha helices connected by a short extended chain of amino acids, which constitute
the turn. The two helices are held at a fixed angle, primarily through interactions
between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed,
p408-9)
