Preferred Label : protein s deficiency;
MeSH definition : An autosomal dominant disorder showing decreased levels of plasma protein S antigen
or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is
a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a
cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical
manifestations of its deficiency are virtually identical to those of protein C deficiency.
Treatment with heparin for acute thrombotic processes is usually followed by maintenance
administration of coumarin drugs for the prevention of recurrent thrombosis. (From
Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology,
9th ed, p1523);
MeSH synonym : deficiencies, protein s; protein s deficiencies; deficiency, protein s; hereditary thrombophilia due to protein S deficiency;
MeSH annotation : a blood protein disord causing thromboses; DF: PROTEIN S DEFIC;
Origin ID : D018455;
UMLS CUI : C0242666;
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An autosomal dominant disorder showing decreased levels of plasma protein S antigen
or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is
a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a
cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical
manifestations of its deficiency are virtually identical to those of protein C deficiency.
Treatment with heparin for acute thrombotic processes is usually followed by maintenance
administration of coumarin drugs for the prevention of recurrent thrombosis. (From
Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology,
9th ed, p1523)
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=743
France
French
rare diseases
protein s deficiency
scientific and technical information
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http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=26349
France
French
scientific and technical information
rare diseases
protein s deficiency
---