protein s deficiency

Preferred Label : protein s deficiency;

MeSH definition : An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523);

MeSH synonym : deficiencies, protein s; protein s deficiencies; deficiency, protein s; hereditary thrombophilia due to protein S deficiency;

MeSH annotation : a blood protein disord causing thromboses; DF: PROTEIN S DEFIC;

Détails

Origin ID

D018455;

UMLS CUI

C0242666;

Allowable qualifiers
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemically induced [MeSH Qualifier]
- classification [MeSH Qualifier]
- complications [MeSH Qualifier]
- congenital [MeSH Qualifier]
- diagnosis [MeSH Qualifier]
- diagnostic imaging [MeSH Qualifier]
- diet therapy [MeSH Qualifier]
- drug therapy [MeSH Qualifier]
- economics [MeSH Qualifier]
- embryology [MeSH Qualifier]
- enzymology [MeSH Qualifier]
- epidemiology [MeSH Qualifier]
- ethnology [MeSH Qualifier]
- etiology [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- microbiology [MeSH Qualifier]
- mortality [MeSH Qualifier]
- nursing [MeSH Qualifier]
- parasitology [MeSH Qualifier]
- pathology [MeSH Qualifier]
- physiopathology [MeSH Qualifier]
- prevention and control [MeSH Qualifier]
- psychology [MeSH Qualifier]
- radiotherapy [MeSH Qualifier]
- rehabilitation [MeSH Qualifier]
- surgery [MeSH Qualifier]
- therapy [MeSH Qualifier]
- urine [MeSH Qualifier]
- veterinary [MeSH Qualifier]
- virology [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Primary thrombophilia [ICD-10 Sub-category]
- Protein C deficiency [PASCAL descriptor]
- Protein C deficiency [MedDRA Preferred Term]
- Protein deficiency [MedDRA Preferred Term]
- Protein z deficiency [OMIM Phenotype]
- protein S deficiency [DO Concept]
Currated CISMeF NLP mapping
- Protein S Deficiency Disease [NCIt concept]
- Protein S deficiency [MedDRA Preferred Term]
- Protein S deficiency disease (disorder) [SNOMED CT concept]
- Reduced protein S activity [HPO term]
DO Cross reference
- protein S deficiency [DO Concept]
HPO term
- Reduced protein S activity [HPO term]
MeSH Descriptor(s) used for indexing
- protein S [MeSH Descriptor]
Record concept(s)
- protein S deficiency [MeSH concept]
Related MeSH Supplementary Concept(s)
- acquired protein S deficiency [MeSH Supplementary Concept]
- thrombophilia, hereditary, due to protein S deficiency, autosomal dominant [MeSH Supplementary Concept]
- thrombophilia, hereditary, due to protein S deficiency, autosomal recessive [MeSH Supplementary Concept]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Protein S Deficiency Disease [NCIt concept]
- Protein S deficiency [MedDRA Preferred Term]
- Protein S deficiency disease (disorder) [SNOMED CT concept]
- protein S deficiency [DO Concept]
- protein s deficiency disease [SNOMED Notion]

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