leukotriene a4

Preferred Label : leukotriene a4;

MeSH definition : (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990);

MeSH synonym : leukotriene a 4; leukotriene a-4; lta4;

MeSH Hyperonym : leukotriene A; Leukotrienes A;

MeSH annotation : /biosyn /physiol permitted;

Is substance : O;

Details

Origin ID

D017572;

UMLS CUI

C0125631;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- LTA4H wt Allele [NCIt concept]
- Leukotriene [NCIt concept]
- Leukotriene (substance) [SNOMED CT concept]
- Leukotriene A (substance) [SNOMED CT concept]
- leukotriene a [SNOMED Notion]
- leukotriene, nos [SNOMED Notion]
- leukotrienes [Artificial nutrition thesaurus concept]
- leukotrienes [IUPAC Term]
Record concept(s)
- leukotriene A [MeSH concept]
- leukotriene A4 [MeSH concept]
Related MeSH Supplementary Concept(s)
- 11,12-leukotriene A4 [MeSH Supplementary Concept]
- 14,15-dehydroleukotriene A4 [MeSH Supplementary Concept]
- 14,15-leukotriene A4 [MeSH Supplementary Concept]
- 19-((2-azido-5-iodo)benzoyloxy)leukotriene A(4) [MeSH Supplementary Concept]
- 19-((2-azido-5-trimethylstannyl)benzoyloxy)leukotriene A(4) [MeSH Supplementary Concept]
- 5,6-methanoleukotriene A4 [MeSH Supplementary Concept]
- leukotriene A methyl ester [MeSH Supplementary Concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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