Cellular Senescence

Preferred Label : Cellular Senescence;

MeSH definition : The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.; Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.;

MeSH synonym : senescence, cellular; cell senescence; senescence, cell;

CISMeF synonym : cell aging;

DeCS synonym : Senescence-Associated Secretory Phenotype; Cellular Ageing; Cell Aging; Senescence Associated Secretory Phenotype;

MeSH hyponym : Cellular Ageing; Ageing, Cellular; Aging, Cell; Senescence, Replicative; Cellular Aging; Aging, Cellular; Replicative Senescence; Cell Ageing; Ageing, Cell;

Related MeSH term : Phenotype, Senescence-Associated Secretory; Secretory Phenotype, Senescence-Associated; Senescence Associated Secretory Phenotype;

MeSH annotation : not for micro-organisms;

Wikipedia link : https://en.wikipedia.org/wiki/Cellular senescence;

Details

Origin ID

D016922;

UMLS CUI

C0007581;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- cell aging [GO term]
- replicative senescence [GO term]
Currated CISMeF NLP mapping
- Cell Aging [NCIt concept]
- cellular senescence [GO term]
Indexing information
- DKK3 protein, human [MeSH Supplementary Concept]
- ZNF410 protein, human [MeSH Supplementary Concept]
Record concept(s)
- Cell Aging [MeSH concept]
- Cellular Senescence [MeSH concept]
See also
- Plant Senescence [MeSH Descriptor]
- aging [MeSH Descriptor]
- cell death [MeSH Descriptor]
See also inter- (CISMeF)
- senolytic [SYNODOS term]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- Cell Aging [NCIt concept]
- cell aging [GO term]
- cellular senescence [GO term]
- replicative senescence [GO term]

Keyword's position in hierarchy(ies) :

Main resources

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