" /> oncogene protein gp140(v-fms) - CISMeF





Preferred Label : oncogene protein gp140(v-fms);

MeSH definition : Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).;

MeSH synonym : fms oncogene product gp140; fms oncogene protein gp140; gp140(v-fms); v-fms, gp140; v-fms protein; v fms protein; gp140 v-fms; gp140 v fms;

MeSH hyponym : fms oncogene protein gp120; gp120(v-fms); fms oncogene product gp120; gp120 v-fms; gp120 v fms; v-fms, gp120;

MeSH annotation : IM; coord with specific virus (IM); /drug eff /ultrastruct permitted; DF: note short X refs; IM; coord with specific virus (IM); /drug eff /ultrastruct permitted;

Is substance : O;

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Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).

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30/04/2025


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