Preferred Label : integrins;
MeSH definition : A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent
heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR
MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact
with the CYTOSKELETON. The integrins consist of at least three identified families:
the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors
(RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family
contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct
alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix
and cell-cell adhesion in many physiologically important processes, including embryological
development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms;
and oncogenic transformation.; A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent
heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR
MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact
with the CYTOSKELETON. The integrins consist of at least three identified families:
the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors
(RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family
contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct
alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix
and cell-cell adhesion in many physiologically important processes, including embryological
development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms;
and oncogenic transformation.;
MeSH synonym : Integrin;
MeSH annotation : prefer specifics;
Wikipedia link : https://en.wikipedia.org/wiki/Integrin;
Is substance : O;
Origin ID : D016023;
UMLS CUI : C0021701;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Indexing information
- LDP-02 [MeSH Supplementary Concept]
- SM 256 [MeSH Supplementary Concept]
- Ne pas confondre avec
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- See also (suggested by CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent
heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR
MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact
with the CYTOSKELETON. The integrins consist of at least three identified families:
the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors
(RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family
contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct
alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix
and cell-cell adhesion in many physiologically important processes, including embryological
development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms;
and oncogenic transformation.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent
heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR
MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact
with the CYTOSKELETON. The integrins consist of at least three identified families:
the cytoadhesin receptors (RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors
(RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family
contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct
alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix
and cell-cell adhesion in many physiologically important processes, including embryological
development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms;
and oncogenic transformation.
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=34520
France
French
rare diseases
muscular dystrophies
integrins
scientific and technical information
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https://www.jle.com/fr/revues/medecine/hma/e-docs/00/02/23/B3/resume.md
2001
France
French
hematopoietic stem cells
integrins
hematopoietic system
hematopoiesis
selectins
sialomucins
journal article
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