MeSH definition : Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved
by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a
metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic
activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation
to factor Va.;
Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved
by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a
metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic
activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation
to factor Va.