Preferred Label : complement C5a;
MeSH definition : The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B.
C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial
for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is
the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE),
smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site
of INFLAMMATION.;
MeSH synonym : component 5a, complement; c5a complement; c5a, complement; complement 5a; complement component 5a; complement, C5a;
CISMeF synonym : 5a, complement component;
MeSH CAS label : complement C5a;
Registry Number MeSH : 80295-54-1;
Is substance : O;
Origin ID : D015936;
UMLS CUI : C0009521;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Indexing information
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- C5aRAD [MeSH Supplementary Concept]
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B.
C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial
for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is
the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE),
smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site
of INFLAMMATION.
