MeSH definition : A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING
CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority
of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE
but rarely elsewhere. The presence of gastrinoma is one of three requirements to be
met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families
with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).;
A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING
CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority
of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE
but rarely elsewhere. The presence of gastrinoma is one of three requirements to be
met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families
with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).