signal transduction

Preferred Label : signal transduction;

MeSH definition : The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.;

MeSH synonym : signal transduction systems; transductions, signal; transduction, signal; signal transduction system; system, signal transduction; signal transductions; systems, signal transduction; Cell Signaling;

MeSH hyponym : signal pathways; signal transduction pathways; Receptor-Mediated signal transduction; Pathway, Signal; Pathways, Signal; Signal Pathway; Pathway, Signal Transduction; Pathways, Signal Transduction; Signal Transduction Pathway; Receptor-Mediated Signal Transductions; Signal Transduction, Receptor-Mediated; Signal Transductions, Receptor-Mediated; Receptor Mediated Signal Transduction;

Wikipedia link : https://en.wikipedia.org/wiki/Signal transduction;

Details

Origin ID

D015398;

UMLS CUI

C0037083;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Signal transduction [PASCAL theme]
- signal transduction [COVID-19 Thesaurus concept]
CISMeF manual mappings
- Signaling pathway [OMIConto structure]
Currated CISMeF NLP mapping
- Signal Transduction [NCIt concept]
- Signal transduction, function (observable entity) [SNOMED CT concept]
- Signaling Pathway [NCIt concept]
- signal transduction [SNOMED Notion]
- signal transduction [GO term]
Indexing information
- 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene [MeSH Supplementary Concept]
- 1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene [MeSH Supplementary Concept]
- ABI2 protein, arabidopsis [MeSH Supplementary Concept]
- AEX-1 protein, C elegans [MeSH Supplementary Concept]
- AHP1 protein, arabidopsis [MeSH Supplementary Concept]
- AHP2 protein, arabidopsis [MeSH Supplementary Concept]
- AHP3 protein, arabidopsis [MeSH Supplementary Concept]
- ANKK1 protein, human [MeSH Supplementary Concept]
- ARG1 protein, arabidopsis [MeSH Supplementary Concept]
- ARL protein, arabidopsis [MeSH Supplementary Concept]
- ARL1 protein, arabidopsis [MeSH Supplementary Concept]
- ARL2 protein, arabidopsis [MeSH Supplementary Concept]
- ARR11 protein, arabidopsis [MeSH Supplementary Concept]
- ARR15 protein, arabidopsis [MeSH Supplementary Concept]
- ARR16 protein, arabidopsis [MeSH Supplementary Concept]
- ARR22 protein, arabidopsis [MeSH Supplementary Concept]
- AT2G27250 protein, Arabidopsis [MeSH Supplementary Concept]
- AcfB protein, vibrio cholerae [MeSH Supplementary Concept]
- AmpG protein, bacteria [MeSH Supplementary Concept]
- Apela protein, zebrafish [MeSH Supplementary Concept]
- AsgA protein, myxococcus xanthus [MeSH Supplementary Concept]
- BCAR3 protein, human [MeSH Supplementary Concept]
- BEX3 protein, human [MeSH Supplementary Concept]
- BKI1 protein, arabidopsis [MeSH Supplementary Concept]
- BRI1 protein, arabidopsis [MeSH Supplementary Concept]
- Bex3 protein, rat [MeSH Supplementary Concept]
- BpdT protein, rhodococcus sp. M5 [MeSH Supplementary Concept]
- BvgA protein, bacteria [MeSH Supplementary Concept]
- CD3 epsilon, wallaby [MeSH Supplementary Concept]
- CD300C protein, human [MeSH Supplementary Concept]
- CD3E protein, human [MeSH Supplementary Concept]
- CD3epsilon protein, bovine [MeSH Supplementary Concept]
- CDC55 protein, candida tropicalis [MeSH Supplementary Concept]
- CG-1 protein, parsley [MeSH Supplementary Concept]
- CIPK3 protein, arabidopsis [MeSH Supplementary Concept]
- COPS2 protein, human [MeSH Supplementary Concept]
- CRK protein, human [MeSH Supplementary Concept]
- CesR protein, listeria monocytogenes [MeSH Supplementary Concept]
- CitA protein, E coli [MeSH Supplementary Concept]
- CpxA protein, E coli [MeSH Supplementary Concept]
- CpxA protein, bacteria [MeSH Supplementary Concept]
- CutR protein, streptomyces sp. [MeSH Supplementary Concept]
- CutS protein, streptomyces sp. [MeSH Supplementary Concept]
- DAF-14 protein, C elegans [MeSH Supplementary Concept]
- DAF-3 protein, C elegans [MeSH Supplementary Concept]
- DOCK1 protein, human [MeSH Supplementary Concept]
- DOK2 protein, human [MeSH Supplementary Concept]
- DcuR protein, E coli [MeSH Supplementary Concept]
- Dok3 protein, mouse [MeSH Supplementary Concept]
- Dos protein, Drosophila [MeSH Supplementary Concept]
- EAST protein, drosophila [MeSH Supplementary Concept]
- EAST protein, human [MeSH Supplementary Concept]
- EGL-10 protein, C elegans [MeSH Supplementary Concept]
- EspA protein, E coli [MeSH Supplementary Concept]
- EvgA protein, E coli [MeSH Supplementary Concept]
- FIZ1 protein, human [MeSH Supplementary Concept]
- FOXH1 protein, human [MeSH Supplementary Concept]
- FOXH1 protein, xenopus [MeSH Supplementary Concept]
- FRMD4B protein, human [MeSH Supplementary Concept]
- FRS2alpha protein, mouse [MeSH Supplementary Concept]
- Fiz1 protein, mouse [MeSH Supplementary Concept]
- FlhA protein, bacteria [MeSH Supplementary Concept]
- FlhR protein, paracoccus denitrificans [MeSH Supplementary Concept]
- Foxh1 protein, mouse [MeSH Supplementary Concept]
- FrzZ protein, myxococcus xanthus [MeSH Supplementary Concept]
- GDAP protein [MeSH Supplementary Concept]
- GPB1 protein, S cerevisiae [MeSH Supplementary Concept]
- Gdt1 protein, dictyostelium discoideum [MeSH Supplementary Concept]
- GlnJ protein, rhodospirillum rubrum [MeSH Supplementary Concept]
- GlnK protein, rhodospirillum rubrum [MeSH Supplementary Concept]
- GtcR protein, bacillus brevis [MeSH Supplementary Concept]
- GtcS protein, bacillus brevis [MeSH Supplementary Concept]
- HCK protein, Xenopus [MeSH Supplementary Concept]
- HtrII protein, halobacterium salinarium [MeSH Supplementary Concept]
- HtrII protein, natronobacterium pharaonis [MeSH Supplementary Concept]
- IGBP1 protein, human [MeSH Supplementary Concept]
- Igbp1 protein, mouse [MeSH Supplementary Concept]
- Igbp1b protein, mouse [MeSH Supplementary Concept]
- KSR-1 protein kinase [MeSH Supplementary Concept]
- Kif7 protein, zebrafish [MeSH Supplementary Concept]
- L protein, Drosophila [MeSH Supplementary Concept]
- LFNG protein, Xenopus [MeSH Supplementary Concept]
- LIME1 protein, human [MeSH Supplementary Concept]
- LIN-7 protein, C elegans [MeSH Supplementary Concept]
- LRR1 protein, human [MeSH Supplementary Concept]
- LSCPR1 protein, lymnaea stagnalis [MeSH Supplementary Concept]
- LSCPR2 protein, lymnaea stagnalis [MeSH Supplementary Concept]
- MAPK8IP2 protein, human [MeSH Supplementary Concept]
- MED15 protein, Xenopus [MeSH Supplementary Concept]
- MFNG protein, human [MeSH Supplementary Concept]
- MON1B protein, human [MeSH Supplementary Concept]
- Mapk8ip2 protein, mouse [MeSH Supplementary Concept]
- Med protein, Drosophila [MeSH Supplementary Concept]
- Mon1 protein, Drosophila [MeSH Supplementary Concept]
- MprA protein, mycobacterium tuberculosis [MeSH Supplementary Concept]
- MprB protein, mycobacterium tuberculosis [MeSH Supplementary Concept]
- NEDD9 protein, human [MeSH Supplementary Concept]
- NLRP12 protein, human [MeSH Supplementary Concept]
- NLRP6 protein, human [MeSH Supplementary Concept]
- Nfam1 protein, mouse [MeSH Supplementary Concept]
- Ngfrap1 protein, mouse [MeSH Supplementary Concept]
- Nle protein, Drosophila [MeSH Supplementary Concept]
- P11 (CBL) [MeSH Supplementary Concept]
- PALA protein, emericella nidulans [MeSH Supplementary Concept]
- PALC protein, emericella nidulans [MeSH Supplementary Concept]
- PALH protein, emericella nidulans [MeSH Supplementary Concept]
- PALI protein, emericella nidulans [MeSH Supplementary Concept]
- PARK7 protein, human [MeSH Supplementary Concept]
- PARK7 protein, mouse [MeSH Supplementary Concept]
- PDCD6IP protein, Xenopus [MeSH Supplementary Concept]
- PIAS4 protein, human [MeSH Supplementary Concept]
- PIL6 protein, arabidopsis [MeSH Supplementary Concept]
- PK1M peptide [MeSH Supplementary Concept]
- PLAAT1 protein, human [MeSH Supplementary Concept]
- PLEKHA1 protein, human [MeSH Supplementary Concept]
- PLEKHA2 protein, human [MeSH Supplementary Concept]
- PRK1 protein, petunia inflata [MeSH Supplementary Concept]
- Pias3 protein, mouse [MeSH Supplementary Concept]
- PleD protein, caulobacter crescentus [MeSH Supplementary Concept]
- Plekha1 protein, mouse [MeSH Supplementary Concept]
- Plekha2 protein, mouse [MeSH Supplementary Concept]
- Ppm1h protein, rat [MeSH Supplementary Concept]
- PrhJ protein, ralstonia solanacearum [MeSH Supplementary Concept]
- QrsA protein, coxiella burnetii [MeSH Supplementary Concept]
- RGS11 protein, human [MeSH Supplementary Concept]
- RGS6 protein, human [MeSH Supplementary Concept]
- RGS7 protein, human [MeSH Supplementary Concept]
- RIC-8 protein, C elegans [MeSH Supplementary Concept]
- RKL1 protein, arabidopsis [MeSH Supplementary Concept]
- RLK902 protein, arabidopsis [MeSH Supplementary Concept]
- RPT2 protein, arabidopsis [MeSH Supplementary Concept]
- RSG7 protein, drosophila [MeSH Supplementary Concept]
- RSS protein, rat [MeSH Supplementary Concept]
- RbsT protein, bacillus subtilis [MeSH Supplementary Concept]
- Rgs11 protein, mouse [MeSH Supplementary Concept]
- Rgs18 protein, mouse [MeSH Supplementary Concept]
- Rgs6 protein, mouse [MeSH Supplementary Concept]
- Rgs6 protein, rat [MeSH Supplementary Concept]
- Rgs7 protein, mouse [MeSH Supplementary Concept]
- Rgs7 protein, rat [MeSH Supplementary Concept]
- Ric8a protein, rat [MeSH Supplementary Concept]
- Ric8b protein, rat [MeSH Supplementary Concept]
- RisA protein, bordetella [MeSH Supplementary Concept]
- RisS protein, bordetella bronchiseptica [MeSH Supplementary Concept]
- RpfG protein, xanthomonas campestris [MeSH Supplementary Concept]
- RprX protein, bacteroides fragilis [MeSH Supplementary Concept]
- RprY protein, bacteroides fragilis [MeSH Supplementary Concept]
- Rv0569 protein, Mycobacterium tuberculosis [MeSH Supplementary Concept]
- SANE protein, xenopus [MeSH Supplementary Concept]
- SDZ 280-961 [MeSH Supplementary Concept]
- SEZ6L protein, human [MeSH Supplementary Concept]
- SF1 protein, S cerevisiae [MeSH Supplementary Concept]
- SF1 protein, human [MeSH Supplementary Concept]
- SGA2 protein, soybean [MeSH Supplementary Concept]
- SH2B2 protein, human [MeSH Supplementary Concept]
- SH2B3 protein, human [MeSH Supplementary Concept]
- SH2D3A protein, human [MeSH Supplementary Concept]
- SH2D3C protein, human [MeSH Supplementary Concept]
- SIMPL protein, mouse [MeSH Supplementary Concept]
- SIS2 protein, candida tropicalis [MeSH Supplementary Concept]
- SMAD9 protein, human [MeSH Supplementary Concept]
- SOCS2 protein, human [MeSH Supplementary Concept]
- SOCS3 protein, human [MeSH Supplementary Concept]
- SOCS4 protein, mouse [MeSH Supplementary Concept]
- SPI-2 protein, salmonella [MeSH Supplementary Concept]
- SPY protein, arabidopsis [MeSH Supplementary Concept]
- SSK1 protein, candida albicans [MeSH Supplementary Concept]
- STAM protein, human [MeSH Supplementary Concept]
- STATc protein, dictyostelium [MeSH Supplementary Concept]
- STK24 protein, human [MeSH Supplementary Concept]
- Sf1 protein, mouse [MeSH Supplementary Concept]
- Sf1 protein, rat [MeSH Supplementary Concept]
- Sfrp2 protein, mouse [MeSH Supplementary Concept]
- Sh2b3 protein, rat [MeSH Supplementary Concept]
- Sh2d3c protein, mouse [MeSH Supplementary Concept]
- Shroom1 protein, Xenopus [MeSH Supplementary Concept]
- Smad4 protein, mouse [MeSH Supplementary Concept]
- Smad4 protein, rat [MeSH Supplementary Concept]
- Smad8 protein, xenopus [MeSH Supplementary Concept]
- Smad9 protein, mouse [MeSH Supplementary Concept]
- Smad9 protein, rat [MeSH Supplementary Concept]
- Socs2 protein, mouse [MeSH Supplementary Concept]
- Socs2 protein, rat [MeSH Supplementary Concept]
- Socs3 protein, mouse [MeSH Supplementary Concept]
- Socs3 protein, rat [MeSH Supplementary Concept]
- SphR protein, synechococcus sp. [MeSH Supplementary Concept]
- SphS protein, synechococcus sp. [MeSH Supplementary Concept]
- SrhS protein, staphylococcus aureus [MeSH Supplementary Concept]
- StNAC protein, solanum tuberosum [MeSH Supplementary Concept]
- Stam2 protein, mouse [MeSH Supplementary Concept]
- Stk24 protein, mouse [MeSH Supplementary Concept]
- StyR protein, pseudomonas [MeSH Supplementary Concept]
- TIRAP protein, human [MeSH Supplementary Concept]
- TIRAP protein, mouse [MeSH Supplementary Concept]
- TOLLIP protein, human [MeSH Supplementary Concept]
- TorS protein, E coli [MeSH Supplementary Concept]
- WD repeat containing planar cell polarity effector [MeSH Supplementary Concept]
- Wdr12 protein, mouse [MeSH Supplementary Concept]
- YfiJ protein, bacillus subitlis [MeSH Supplementary Concept]
- aer protein, E coli [MeSH Supplementary Concept]
- agr protein, staphylococcus aureus [MeSH Supplementary Concept]
- apx-1 protein, C elegans [MeSH Supplementary Concept]
- arcB protein, E coli [MeSH Supplementary Concept]
- bvgS protein, bordetella pertussis [MeSH Supplementary Concept]
- cbl protein, drosophila [MeSH Supplementary Concept]
- cos protein, drosophila [MeSH Supplementary Concept]
- crr protein, E coli [MeSH Supplementary Concept]
- ctr1 protein, synechocystis [MeSH Supplementary Concept]
- cyclo(Phe-Phe-Pro-Trp-Gly-Ala) [MeSH Supplementary Concept]
- cycloepoxydon [MeSH Supplementary Concept]
- cytokine inducible SH2-containing protein [MeSH Supplementary Concept]
- dixdc1a protein, zebrafish [MeSH Supplementary Concept]
- dome protein, Drosophila [MeSH Supplementary Concept]
- edl protein, Drosophila [MeSH Supplementary Concept]
- fng protein, drosophila [MeSH Supplementary Concept]
- foxh1 protein, zebrafish [MeSH Supplementary Concept]
- frizzled related protein-3 [MeSH Supplementary Concept]
- hepatocyte growth factor-regulated tyrosine kinase substrate [MeSH Supplementary Concept]
- lin-45 protein, C elegans [MeSH Supplementary Concept]
- lnk protein, mouse [MeSH Supplementary Concept]
- mbc protein, Drosophila [MeSH Supplementary Concept]
- mecR1 protein, staphylococcus aureus [MeSH Supplementary Concept]
- mfng protein, mouse [MeSH Supplementary Concept]
- narQ protein, E coli [MeSH Supplementary Concept]
- narX protein, E coli [MeSH Supplementary Concept]
- ndl protein, Drosophila [MeSH Supplementary Concept]
- notchless protein, mouse [MeSH Supplementary Concept]
- nrarp protein, mouse [MeSH Supplementary Concept]
- nrarp protein, xenopus [MeSH Supplementary Concept]
- nrarpa protein, zebrafish [MeSH Supplementary Concept]
- nrarpb protein, zebrafish [MeSH Supplementary Concept]
- p260 palmitoyltransferase [MeSH Supplementary Concept]
- p270 palmitoyltransferase [MeSH Supplementary Concept]
- pfeR protein, pseudomonas aeruginosa [MeSH Supplementary Concept]
- piasy protein, mouse [MeSH Supplementary Concept]
- protein kinase-phosphatase NTRB [MeSH Supplementary Concept]
- qk protein, mouse [MeSH Supplementary Concept]
- rasp protein, drosophila [MeSH Supplementary Concept]
- rcsD protein, E coli [MeSH Supplementary Concept]
- regulatory protein uridylyltransferase [MeSH Supplementary Concept]
- ric8b protein, zebrafish [MeSH Supplementary Concept]
- sesquicillin [MeSH Supplementary Concept]
- sfa-1 protein, C elegans [MeSH Supplementary Concept]
- sma-2 protein, C elegans [MeSH Supplementary Concept]
- stam protein, mouse [MeSH Supplementary Concept]
- sterile 20-like protein kinase nerve injury-associated kinase [MeSH Supplementary Concept]
- tollip protein, mouse [MeSH Supplementary Concept]
- wgn protein, Drosophila [MeSH Supplementary Concept]
- white collar 2 protein, neurospora [MeSH Supplementary Concept]
Record concept(s)
- Receptor-Mediated signal transduction [MeSH concept]
- signal pathways [MeSH concept]
- signal transduction [MeSH concept]
- signal transduction pathways [MeSH concept]
Related MeSH Supplementary Concept(s)
- C16orf54 protein, human [MeSH Supplementary Concept]
- IKBIP protein, human [MeSH Supplementary Concept]
- NEVER-RIPE protein, lycopersicon esculentum [MeSH Supplementary Concept]
See also
- Receptor-CD3 complex, antigen, T-Cell [MeSH Descriptor]
- cell communication [MeSH Descriptor]
- feedback, physiological [MeSH Descriptor]
- gasotransmitters [MeSH Descriptor]
- ion channels [MeSH Descriptor]
- receptor cross-talk [MeSH Descriptor]
See also inter- (CISMeF)
- Signaling pathway analysis [OMIConto index]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- Signal Transduction [NCIt concept]
- Signal transduction, function (observable entity) [SNOMED CT concept]
- signal transduction [GO term]
- signal transduction [SNOMED Notion]

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