Preferred Label : transducin;
MeSH definition : A heterotrimeric GTP-binding protein that mediates the light activation signal from
photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual
excitation process. Activation of rhodopsin on the outer membrane of rod and cone
cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP
complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex
activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic
GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore
hyperpolarization of the rod cells. EC 3.6.1.-.; A heterotrimeric GTP-binding protein that mediates the light activation signal from
photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual
excitation process. Activation of rhodopsin on the outer membrane of rod and cone
cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP
complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex
activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic
GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore
hyperpolarization of the rod cells.;
MeSH synonym : g-protein, inhibitory gt; gt, transducin g-protein; inhibitory gt g-protein; transducin g-protein gt; g protein, inhibitory gt; gt g-protein, inhibitory; transducin g-protein (gt); g-protein gt, transducin; gt, transducin g protein;
MeSH hyponym : beta-Transducin; gamma-Transducin; alpha-Transducin; gamma Transducin; Transducin, gamma Subunit; gamma Subunit Transducin; beta Transducin; Transducin, beta Subunit; beta Subunit Transducin; alpha Transducin; Transducin, alpha Subunit; alpha Subunit Transducin;
Registry Number MeSH : EC 3.6.1.-; EC 3.6.5.1;
MeSH annotation : alpha, beta and gamma transducins refer to its subunits;
Wikipedia link : https://en.wikipedia.org/wiki/Transducin;
Is substance : O;
UNII : EC 3.6.5.1;
Origin ID : D015293;
UMLS CUI : C0040663;
Allowable qualifiers
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A heterotrimeric GTP-binding protein that mediates the light activation signal from
photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual
excitation process. Activation of rhodopsin on the outer membrane of rod and cone
cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP
complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex
activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic
GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore
hyperpolarization of the rod cells. EC 3.6.1.-.
A heterotrimeric GTP-binding protein that mediates the light activation signal from
photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual
excitation process. Activation of rhodopsin on the outer membrane of rod and cone
cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP
complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex
activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic
GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore
hyperpolarization of the rod cells.
