MeSH definition : Fibrinogens which have a functional defect as the result of one or more amino acid
substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the
fibrinogen molecule may impair any of the major steps involved in the conversion of
fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin,
polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be
clinically silent or can be associated with bleeding, thrombosis or defective wound
healing.;
MeSH synonym : abnormal fibrinogens;
MeSH annotation : have a functional defect as the result of one or more amino acid substitutions in
the amino acid seq of normal fibrinogen; DF: FIBRINOGENS ABNORM;
Fibrinogens which have a functional defect as the result of one or more amino acid
substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the
fibrinogen molecule may impair any of the major steps involved in the conversion of
fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin,
polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be
clinically silent or can be associated with bleeding, thrombosis or defective wound
healing.